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Yellow Fever Vaccination


Yellow Fever is a very serious and sometimes fatal viral disease that is spread by day time mosquitoes in tropical parts of Africa and South America. It occurs in both jungle and urban environments and is particularly common in the rainy season.


Summary

Age of Use

9+ months

Doses Required

Just 1

Schedule

N/A

Time before Travel

10 days

Booster Required

Lifelong

Cost

from £55

When is yellow fever vaccination indicated?

Yellow fever vaccination is only available from designated centres, including Birdsfoot Lane Pharmacy. The following groups should be immunized:

  • Laboratory workers handling infected material.
  • People aged 9 months or older who are travelling to countries that require an International Certificate of Vaccination or Prophylaxis (ICVP) for entry.
  • People aged 9 months or older who are travelling to, or living in, infected areas or countries in the yellow fever endemic zone, even if these countries do not require evidence of immunization on entry.
  • Infants aged 6–9 months should only be immunized if the risk of yellow fever during travel is unavoidable; expert opinion should be sought in these situations.
  • Infants under the age of 5 months should not be given yellow fever vaccine.

For people over 60 years of age expert advice should be sought (increased risk of neurological adverse events).

When is proof of yellow fever vaccination required?

Proof of vaccination (International Certificate of Vaccination or Prophylaxis) maybe required for travellers coming from countries where yellow fever occurs, including transit through such countries.

For a full list of countries that require a valid certificate see the WHO website : http://www.who.int/ith/2016-ith-county-list.pdf

When is yellow fever vaccine contraindicated?

Yellow fever vaccine should not be given to:

  • Anyone aged 5 months or under.
  • Those who have had a confirmed anaphylactic reaction to a previous dose of yellow fever vaccine.
  • Those who have had a confirmed anaphylactic reaction to any of the components of the vaccine.
  • Those who have had a confirmed anaphylactic reaction to egg.
  • Anyone with a thymus disorder.
  • Anyone who is immunocompromised.

If a yellow fever vaccine is required for a woman who is breastfeeding seek specialist advise from National Travel Health Network and Centre (NaTHNaC).

There is some evidence of transmission of the live vaccine virus through breast milk to infants under two months of age. Anyone who must travel and cannot receive a yellow fever vaccine should be informed of the risk of yellow fever and instructed in mosquito bite avoidance measures.

Anyone who is travelling to countries where an International Certificate of Vaccination and Prophylaxis against yellow fever is required for entry, should request that a letter of exemption is issued by the Yellow Fever Vaccination Centre or by the practitioner treating the person. This should be taken into consideration by the port health authorities at the destination.

What are the adverse effects of yellow fever vaccine?

Adverse reactions following yellow fever vaccine are typically mild and consist of headache, myalgia, low grade fever, and/or soreness at the injection site, and will occur in 10–30% of recipients. Injection-site reactions tend to occur from days 1–5 after immunization.

Systemic adverse effects also occur early but may last up to 2 weeks. Up to 1% of individuals may need to alter daily activities due to these.
Rash, urticaria, bronchospasm, and anaphylaxis occur rarely (estimated to be 1 case per 130,000 doses of vaccine).

Post-vaccine encephalitis may occur rarely, particularly in infants (0.5 to 4 cases per 1000 infants under 6 months of age). Rarely, yellow fever vaccine-associated neurological disease (YEL-AND) may occur. YEL-AND begins 4–23 days after vaccination with the onset of fever and headache that may progress to include one or more of: confusion, focal neurological deficits, coma, and Guillain–Barré syndrome. Most people recover completely. All cases have occurred following primary vaccination (in people who have no underlying yellow fever immunity). Rarely, yellow fever vaccine-associated viscerotropic disease (YEL-AVD) may occur.

YEL-AVD begins 2–7 days after vaccination with the onset of fever, malaise, headache, and myalgias that progress to hepatitis, hypotension, and multi-organ failure; death has occurred in more than 60% of reported cases. All cases have occurred following primary vaccination (in people without underlying yellow fever immunity). In the reports of viscerotropic disease, 17% have had a history of thymus disease with subsequent thymectomy. Thus, people with thymus disorders should not receive yellow fever vaccine.

For those who are aged 60 years or older, the risk of neurological and viscerotropic adverse events increases:

Neurological events — 17 cases per million doses.
Viscerotropic events — 21 cases per million doses.
Opening Times
Mon: 9:00am - 6:30pm

Tue: 9:00am - 6:30pm

Wed: 9:00am - 6:30pm

Thur: 9:00am - 6:30pm

Fri: 9:00am - 6:30pm

Sat: 9:00am - 1:00pm

Sun: Closed

Contact us
t: 01582 591 616
e: customerservice@birdsfootpharmacy.co.uk
Birdsfoot Lane Pharmacy
255 Birdsfoot Lane, Luton, Bedfordshire, LU3 2HX
Superintendent Pharmacist : Mr Rupesh Shah
GPhC Pharmacist Reg No. : 2048914
GPhC Premises Reg No. : 1028845
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